Which pharmaceutical product was the first blockbuster drug to reach annual sales of $1 billion and revolutionized the treatment of ulcers?

The pharmaceutical and medical device industry has seen numerous groundbreaking products that have transformed healthcare delivery and patient outcomes. Some innovations have been so revolutionary that they've become household names, while others have quietly saved millions of lives. This trivia question tests your knowledge about a famous medical product that changed the landscape of modern medicine. Can you identify the correct fact about this game-changing innovation?

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Tagamet (cimetidine), developed by Smith Kline & French (now GlaxoSmithKline) in 1976
Zantac (ranitidine), developed by Glaxo (now GlaxoSmithKline) in 1981
Prilosec (omeprazole), developed by AstraZeneca in 1989
Nexium (esomeprazole), developed by AstraZeneca in 2001