Which revolutionary scientific instrument was initially criticized as 'useless for biological research' upon its product launch in 1981, but later earned its inventors a Nobel Prize?

Product launches in the scientific field can change the course of medicine, technology, and our understanding of the universe. Some launches receive tremendous fanfare while others quietly revolutionize their fields. This poll tests your knowledge about a significant scientific product launch that challenged conventional thinking and opened new research pathways. Do you know the details behind this groundbreaking scientific tool's introduction to the market?

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Scanning Tunneling Microscope (STM)
Polymerase Chain Reaction (PCR) Machine
CRISPR-Cas9 Gene Editing Tool
Automated DNA Sequencer