Which scientific product design innovation led to the 2014 Nobel Prize in Chemistry for dramatically surpassing the diffraction limit in optical microscopy?

Product design in science often involves groundbreaking innovations that change how researchers and laboratories operate. Some scientific instruments revolutionize entire fields by enabling new types of measurements or dramatically improving efficiency. This poll tests your knowledge about a pivotal product design that transformed modern scientific research capabilities.

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Super-resolution fluorescence microscopy (nanoscopy)
Atomic force microscopy (AFM) with carbon nanotube tips
Cryo-electron holographic tomography
Quantum dot enhanced digital imaging systems