Which scientific instrument, first commercially produced in the 1980s, directly enabled research that led to THREE different Nobel Prizes in Chemistry between 1993 and 2020?

The Nobel Prize represents the pinnacle of scientific achievement and product innovation. Behind many Nobel Prize-winning discoveries are innovative research tools and technologies that revolutionized scientific methodology. This trivia question explores how product innovation in laboratory equipment has transformed scientific research capabilities and led to groundbreaking discoveries worthy of recognition at the highest level. Test your knowledge about the intersection of scientific product development and prestigious awards!

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Polymerase Chain Reaction (PCR) machine
Scanning Tunneling Microscope (STM)
Nuclear Magnetic Resonance (NMR) spectrometer
X-ray Crystallography diffractometer