Which of these now-essential medications was initially rejected by most physicians and had first-year sales of less than $1 million, nearly causing its manufacturer to discontinue it before becoming a blockbuster?

The pharmaceutical industry has had its share of surprising product launches - some that seemed destined for failure but became revolutionary successes. This poll tests your knowledge about one of the most remarkable product launch stories in medical history, where initial skepticism nearly derailed what would become a breakthrough treatment. Can you identify which of these now-common medications faced extraordinary resistance during its initial market introduction?

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Lipitor (atorvastatin) - launched with concerns about liver toxicity compared to existing statins
Prozac (fluoxetine) - initially dismissed as no better than existing tricyclic antidepressants with a controversial mechanism
Humira (adalimumab) - faced resistance due to its high cost and injectable administration route
Cialis (tadalafil) - launched into a market dominated by Viagra with skepticism about its 36-hour duration claim