Which pharmaceutical product recall led to the most comprehensive overhaul of FDA safety regulations in the 2000s?

In the pharmaceutical world, product recalls can have far-reaching consequences, reshaping industry regulations and patient safety protocols. One particular recall stands out as having triggered the most significant regulatory changes in the 21st century. Test your knowledge of this pivotal moment in medical product safety history that fundamentally transformed how pharmaceutical companies approach quality control and transparency in their operations.

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Vioxx (rofecoxib) - Merck's arthritis medication recalled in 2004 after links to increased heart attack and stroke risks
Baycol (cerivastatin) - Bayer's cholesterol-lowering drug withdrawn in 2001 due to reports of fatal rhabdomyolysis
Rezulin (troglitazone) - Warner-Lambert's diabetes drug removed in 2000 after causing severe liver damage
Bextra (valdecoxib) - Pfizer's pain medication withdrawn in 2005 due to cardiovascular risks and severe skin reactions