Which medication class was the first to receive a mandatory FDA Black Box Warning as part of its marketing requirements?

The pharmaceutical industry faces unique marketing challenges with strict regulatory oversight. One of the most significant tools in pharmaceutical risk communication is the FDA's 'Black Box Warning' - the strongest warning that appears on prescription drug labels. These warnings highlight serious or life-threatening risks and have dramatically changed how certain medications are marketed and prescribed. Test your knowledge about this critical intersection of medical product safety and marketing communication.

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Oral contraceptives (1978)
Benzodiazepines (1982)
Tricyclic antidepressants (1975)
Isotretinoin/Accutane (1985)