Which scientific product development breakthrough was famously rejected by its own company's management before becoming a billion-dollar innovation?

In the competitive world of scientific product development, companies often race to be the first to market with groundbreaking innovations. This can involve years of research, extensive testing, and navigating complex regulatory pathways. How well do you know the stories behind some of science's most transformative commercial products? Test your knowledge of the intersection between scientific discovery and product development with this challenging question!

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Post-it Notes at 3M, originally created when Spencer Silver developed a 'weak' adhesive that management saw no use for
The HPV vaccine at Merck, initially dismissed as having too small a market before becoming standard preventive care
The graphene isolation technique at IBM, rejected as impractical before winning its external developers a Nobel Prize
CRISPR gene editing technology at Pfizer, declined internally before becoming the foundation of numerous biotech startups