Which scientific product design innovation was initially rejected by the scientific community but later revolutionized genetic research and won its creator a Nobel Prize?

Product design in the scientific industry requires a delicate balance between innovation, functionality, and user experience. Companies must navigate complex regulatory requirements while creating products that meet the exacting standards of scientific professionals. This poll tests your knowledge of a famous product design decision that significantly impacted scientific research methodology. How well do you know the stories behind the tools that power modern science?

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Polymerase Chain Reaction (PCR) technique developed by Kary Mullis
Electron microscope design by Ernst Ruska
DNA sequencing method by Frederick Sanger
Mass spectrometer design by J.J. Thomson