Which of these pharmaceutical products experienced a massive recall in 1982 that fundamentally changed how medication safety and anti-tampering protocols are regulated in the US?

Product recalls in medicine have shaped healthcare safety protocols and regulatory frameworks. Some recalls have been so significant they've changed the entire industry's approach to safety monitoring. This trivia question explores one of the most impactful pharmaceutical product recalls in modern medical history that led to substantial changes in drug safety regulations and monitoring worldwide.

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Tylenol (acetaminophen) capsules
Vioxx (rofecoxib) pain medication
Thalidomide sedative tablets
Bextra (valdecoxib) anti-inflammatory drug