Which of these scientific product launches represented the most significant breakthrough in DNA research methodology when first introduced to the market?

Scientific breakthroughs often depend on innovative tools and technologies. Throughout history, certain product launches in the scientific field have revolutionized how research is conducted, accelerating discoveries and opening new frontiers of knowledge. This trivia question tests your knowledge about a particularly transformative product launch that changed the landscape of scientific research. Can you identify which of these scientific instruments represented the biggest paradigm shift in its field when first introduced?

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The Illumina HiSeq 2000 (2010), which reduced the cost of genome sequencing from millions to thousands of dollars
The Oxford Nanopore MinION (2014), which enabled portable DNA sequencing in the field
The PCR machine by Cetus Corporation (1985), which enabled amplification of DNA fragments for analysis
The Applied Biosystems DNA Synthesizer (1981), which automated the creation of custom DNA sequences