Which historic brand collaboration led to the first commercially successful synthetic human insulin product in the 1980s?

In the pharmaceutical industry, strategic brand collaborations can lead to groundbreaking medical innovations that change patient care forever. Some partnerships have resulted in revolutionary drug delivery systems, while others have combined expertise to tackle previously untreatable conditions. This trivia question focuses on one of the most significant pharmaceutical collaborations in recent medical history that transformed diabetes treatment worldwide.

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Genentech and Eli Lilly (Humulin)
Merck and Pfizer (Insugen)
Bayer and Johnson & Johnson (Novolin)
Roche and GlaxoSmithKline (Lantus)