Which scientific product innovation was initially rejected by the scientific community but later won a Nobel Prize and revolutionized DNA research?

The field of scientific research and product development is constantly evolving, with companies racing to pioneer new technologies and innovations. This poll tests your knowledge about a significant scientific product innovation that revolutionized laboratory research and analysis. Consider how this innovation changed scientific workflows and enabled new discoveries before selecting your answer.

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Polymerase Chain Reaction (PCR)
Nuclear Magnetic Resonance (NMR) Spectroscopy
Transmission Electron Microscopy (TEM)
High-Performance Liquid Chromatography (HPLC)