Which design innovation for insulin delivery devices has most dramatically improved quality of life for diabetic patients in the last 20 years?

The design of medical devices and products has evolved dramatically over the decades, often balancing innovation with patient safety. This trivia question explores how product design in medicine has been influenced by user feedback and real-world application. See if you can identify which groundbreaking design change transformed a common medical device and significantly improved patient outcomes.

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The development of continuous glucose monitoring integration with insulin pumps (closed-loop systems)
The introduction of prefilled, disposable insulin pens
The miniaturization of traditional syringe needles to ultra-fine gauges
The development of implantable insulin delivery systems