Which prescription medication became the first pharmaceutical product to reach $1 billion in annual sales (achieving 'blockbuster' status) in the 1980s?

The medical industry has seen numerous revolutionary product launches that have transformed patient care. Some launches stand out not just for the innovation they brought to healthcare but also for their commercial impact. This trivia question tests your knowledge about a significant product launch that made pharmaceutical history.

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Tagamet (cimetidine) - the revolutionary ulcer medication
Prozac (fluoxetine) - the groundbreaking antidepressant
Zantac (ranitidine) - the histamine H2-receptor antagonist
Mevacor (lovastatin) - the first statin cholesterol medication