Which design principle revolutionized insulin pen design in the early 2000s, making them significantly more user-friendly for patients with diabetes?

The design of medical devices has evolved dramatically over the decades, influenced by technological advances, user feedback, and clinical requirements. These innovations have transformed healthcare delivery and patient outcomes. This trivia question explores a significant turning point in medical device design philosophy that changed the industry's approach to user experience.

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Human-centered design focusing on ergonomics and reduced injection force
Miniaturization technology that reduced device size by 75%
Smart connectivity features enabling mobile app integration
Disposable components eliminating the need for sterilization