Which medication became the first pharmaceutical product to achieve annual sales of $1 billion (becoming the first 'blockbuster drug') and pioneered direct-to-consumer marketing in the medical industry?

The pharmaceutical industry has seen numerous marketing successes throughout its history, with some medications becoming household names. Behind these successful products are fascinating stories of product marketing, brand development, and market penetration strategies. This trivia question explores a significant milestone in pharmaceutical marketing history that changed how medications were promoted to both healthcare providers and patients.

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Tagamet (cimetidine) - the groundbreaking ulcer medication by SmithKline
Prozac (fluoxetine) - Eli Lilly's revolutionary antidepressant
Zantac (ranitidine) - Glaxo's H2 blocker that dominated the 1980s market
Valium (diazepam) - Roche's anxiety medication that transformed psychiatric treatment