Which significant regulatory change in the 1990s revolutionized pharmaceutical advertising in the United States?

The pharmaceutical industry has a fascinating history of advertising techniques that have evolved dramatically over time. From the early patent medicines with exaggerated claims to today's highly regulated direct-to-consumer advertisements, medical marketing has transformed how medications reach patients. This trivia question explores a pivotal moment in pharmaceutical advertising history that changed how medications are marketed to the public.

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The FDA allowed direct-to-consumer (DTC) television advertising of prescription drugs
Pharmaceutical companies were first required to list all side effects in print advertisements
Medical journals were prohibited from accepting pharmaceutical advertising
The introduction of the first pharmaceutical company social media campaigns