Which pharmaceutical product was the first to surpass $1 billion in direct-to-consumer advertising spending, revolutionizing medical product marketing in the early 2000s?

In the competitive pharmaceutical industry, product marketing often walks a fine line between informative and promotional content. One particular marketing campaign in the early 2000s revolutionized how prescription medications were advertised directly to consumers, creating a new paradigm in pharmaceutical product promotion. This campaign combined emotional appeal with educational content in a way that transformed the industry's approach to marketing prescription drugs.

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Lipitor (atorvastatin)
Prozac (fluoxetine)
Claritin (loratadine)
Viagra (sildenafil)